Genetic Testing Medical Policies

Commercial | QUEST Integration | Medicare Advantage


Hawaii Medical Service Association (HMSA) partners with Avalon Healthcare Solutions (AHS) to streamline the management of genetic testing services. AHS and HMSA review genetic testing medical policies and services using the HRS-432 - Hawaii State Statute for Medical Necessity. For full medical necessity criteria, refer to to the genetic testing medical policies below.
For a listing of non-covered genetic testing codes, refer to Codes That Do Not Meet Payment Determination Criteria - Table I. Other relevant information may be found on HMSA’s Pathology and Lab - Claim Documentation Requirements page.

Precertification

Precertification is required for GTM. Please refer to the Genetic Testing Management (GTM) Utilization Review Matrix for a comprehensive listing of service codes which AHS manages on behalf of HMSA. All lines of business – commercial, Medicare, and QUEST Integration – are subject to AHS’ precertification review. Providers may submit precertification requests and/or questions 24/7 via AHS’:
 

Prior Authorization System (PAS) Portal
Phone: (844) 227-5769
Fax: (813) 751-3760

 

CURRENT GENETIC TESTING MEDICAL POLICIES

Policy Name Notices Current Effective Date Policy # Additional Information

A  

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C 

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Chromosomal Microarray   12/01/2025 AHS–M2033 Archived Policies

D 

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E 

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Esophageal Pathology Testing   02/01/2026 AHS–M2171 Archived Policies
         

F 

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Fibromyalgia Testing   02/01/2026 AHS-M2177 Archived Policies

G 

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Gene Expression Profiling and Protein Biomarkers for Prostate Cancer   12/01/2025 AHS–M2166 Archived Policies
General Genetic Testing, Germline Disorders   02/01/2025 AHS-M2145 Archived Policies
General Genetic Testing, Somatic Disorders   06/01/2023 AHS–M2146 Archived Policies
Genetic Cancer Susceptibility Using Next Generation Sequencing 60-day archival notice eff 02/01/2026 06/01/2023 AHS-M2066 Archived Policies
Genetic Markers for Assessing Risk of Cardiovascular Disease   12/01/2025 AHS–M2180 Archived Policies
Genetic Testing and Genetic Expression Profiling in Patients with Cutaneous Melanoma   06/01/2023 AHS–M2029 Archived Policies
Genetic Testing and Genetic Expression Profiling in Patients with Uveal Melanoma   02/01/2026 AHS-M2071 Archived Policies
Genetic Testing for Alpha- and Beta- Thalassemia   12/01/2025 AHS-M2131 Archived Policies
Genetic Testing for Breast, Ovarian, Pancreatic, and Prostate Cancers
Formerly: BRCA
  02/01/2026 AHS–M2003 Archived Policies
Genetic Testing for CHARGE Syndrome   06/01/2023 AHS–M2070 Archived Policies
Genetic Testing for Connective Tissue Disorders   02/01/2026 AHS–M2144 Archived Policies
Genetic Testing for Cystic Fibrosis   12/01/2025 AHS-M2017 Archived Policies
Genetic Testing for Diagnosis of Inherited Peripheral Neuropathies   12/01/2025 AHS-M2072 Archived Policies
Genetic Testing for Duchenne, Becker, Facioscapulohumeral, and Limb-Girdle Muscular Dystrophies   06/01/2023 AHS-M2074 Archived Policies
Genetic Testing for Epilepsy   02/01/2026 AHS-M2075 Archived Policies
Genetic Testing for Familial Alzheimer Disease   12/01/2025 AHS-M2038 Archived Policies
Genetic Testing for Familial Cutaneous Malignant Melanoma   06/01/2023 AHS-M2037 Archived Policies
Genetic Testing for Familial Hypercholesterolemia    12/01/2025 AHS-M2137 Archived Policies
Genetic Testing for Fanconi Anemia   06/01/2023 AHS-M2077 Archived Policies
Genetic Testing for FMR1 Mutations   06/01/2023 AHS-M2028 Archived Policies
Genetic Testing for Germline Mutations of the RET Proto-Oncogene   06/01/2023 AHS-M2078 Archived Policies
Genetic Testing for Hereditary Hearing Loss   12/01/2025 AHS-G2148 Archived Policies
Genetic Testing for Hereditary Hemochromatosis   06/01/2023 AHS-M2012 Archived Policies
Genetic Testing for Hereditary Pancreatitis   12/01/2025 AHS-M2079 Archived Policies
Genetic Testing for Inherited Cardiomyopathies and Channelopathies   06/01/2023 AHS-M2025 Archived Policies
Genetic Testing for Lactase Insufficiency   12/01/2025 AHS-M2080 Archived Policies
Genetic Testing for Li-Fraumeni Syndrome   12/01/2025 AHS-M2081 Archived Policies
Genetic Testing for Lipoprotein(a) Variant(s) as a Decision Aid for Aspirin Treatment and/or CVD Risk Assessment   06/01/2023 AHS-M2082 Archived Policies
Genetic Testing for Mental Health Disorders   06/01/2023 AHS-M2084 Archived Policies
Genetic Testing for Neurodegenerative Disorders   02/01/2026 AHS–M2167 Archived Policies
Genetic Testing for Neurofibromatosis and Related Disorders   12/01/2025 AHS-M2134 Archived Policies
Genetic Testing for Ophthalmologic Conditions   122/01/2025 AHS-M2083 Archived Policies
Genetic Testing for Polyposis Syndrome   02/01/2026 AHS-M2024 Archived Policies
Genetic Testing for PTEN Hamartoma Tumor Syndrome   12/01/2025 AHS-M2087 Archived Policies
Genetic Testing for Rett Syndrome   06/01/2023 AHS-M2088 Archived Policies
Genetic Testing of CADASIL Syndrome   06/01/2023 AHS-M2069 Archived Policies
Genetic Testing of Mitochondrial Disorders   06/01/2023 AHS-M2085 Archived Policies

Genome and Exome Sequencing

Formerly: Whole Genome and Whole Exome Sequencing

  12/01/2025

AHS-M2032

Archived Policies
Genomic Testing for Hematopoietic Neoplasms   02/01/2026 AHS-M2182 Archived Policies

H 

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I 

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J 

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K 

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L 

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Laboratory Procedures Reimbursement Policy   03/01/2025 AHS-R2162 Archived Policies
Liquid Biopsy   02/01/2026 AHS-G2054 Archived Policies
Lynch Syndrome   02/01/2026 AHS-M2004 Archived Policies

M 

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Microsatellite Instability and Tumor Mutational Burden Testing   12/01/2025 AHS-M2178 Archived Policies
Minimal Residual Disease   02/01/2026 AHS-M2175 Archived Policies
Molecular Analysis for Gliomas   02/01/2026 AHS–M2139 Archived Policies

Molecular Diagnostics for Breast Cancer Prognosis

Formerly: Molecular Expression Testing for Breast Cancer Prognosis

  02/01/2026 AHS-M2020 Archived Policies
Molecular Markers in Fine Needle Aspirates of the Thyroid   02/01/2026 AHS-M2108 Archived Policies
Molecular Profiling for Cancers of Unknown Primary Origin   12/01/2025 AHS-M2065 Archived Policies

Molecular Testing for Pulmonary Disease

Formerly: Molecular Testing for Pulmonary Specimens

  02/01/2026 AHS–M2160 Archived Policies
Multigene Expression Assay for Predicting Colon Cancer Recurrence   06/01/2023 AHS-M2111 Archived Policies
Mutation Analysis in Myeloproliferative Neoplasms   02/01/2026 AHS-M2101 Archived Policies

N  

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O 

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P 

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Pancreatic Cancer Risk Testing Using Pancreatitis Cyst Fluid   06/01/2023 AHS-M2114 Archived Policies
Pharmacogenetic Testing   02/01/2026 AHS-M2021 Archived Policies
Pre-Implantation Genetic Testing   02/01/2026 AHS-M2039 Archived Policies
Prenatal Screening (Genetic)   02/01/2026 AHS-M2179 Archived Policies
Prenatal Testing for Fetal Aneuploidy   02/01/2025 AHS-G2055 Archived Policies
Proteogenomic Testing of Individuals with Cancer   02/01/2025 AHS-M2168 Archived Policies
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Red Blood Cell Molecular Testing   12/01/2025 AHS-M2170 Archived Policies

S 

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T 

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Testing for Alpha-1 Antitrypsin Deficiency   02/01/2026 AHS-M2068 Archived Policies
Testing for Autism Spectrum Disorder and Developmental Delay   06/01/2023 AHS-M2176 Archived Policies

Testing for Colorectal Cancer Management

Formerly: KRAS NRAS BRAF Mutation Analysis in Colorectal Cancer

  12/01/2025

AHS-M2026

Archived Policies
Testing for Targeted Therapy of Non-Small-Cell Lung Cancer   12/01/2025 AHS-M2030 Archived Policies
Testing of Homocysteine Metabolism-Related Conditions   06/01/2023 AHS-M2141 Archived Policies
Therapeutic Drug Monitoring for 5-Flurouracil   02/01/2025 AHS-M2067 Archived Policies
Transplant Rejection Testing   02/01/2026 AHS-M2091 Archived Policies

U 

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Use of Common Genetic Variants (single nucleotide polymorphisms) to Predict Risk of Non-Familial Breast Cancer   02/01/2026 AHS-M2126 Archived Policies

V 

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Venous and Arterial Thrombosis Risk Testing   02/01/2026 AHS-M2041 Archived Policies

W 

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X 

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Y 

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Z 

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ARCHIVED GTM POLICIES
Unless otherwise noted, archived policies are inactive. Since archived policies are not updated, these policies will no longer be used when reviewing requests for coverage and these services will no longer require prior authorization, unless noted.
 

Archived Policy Title Policy Versions Archived as of:
BCR-ABL 1 Testing - AHS-M2027 Archived Policies 02/01/2025
Genetic Testing for Acute Myeloid Leukemia - AHS-M2062  Archived Policies 02/01/2025

Revision History

Date Nature of Revision
08/03/2026

Migrated to new platform